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Mean sildenafil plasma concentrations calculated following the administration of an individual oral dose of 100 mg to healthier male volunteers is depicted down below:

Your doctor could possibly have suggested this medication for disorders aside from Those people shown in these drug details posts.

Tend not to take additional Viagra than your medical doctor prescribes. Applying over this can cause really serious side effects.

VIAGRA was revealed to potentiate the hypotensive consequences of nitrates and its administration in sufferers who use nitric oxide donors like natural nitrates or natural and organic nitrites in almost any type is therefore contraindicated [see CONTRAINDICATIONS, DRUG INTERACTIONS, and Scientific PHARMACOLOGY].

Acetildenafil and also other artificial structural analogs of sildenafil that happen to be PDE5 inhibitors have already been observed as adulterants in a number of "herbal" aphrodisiac products offered in excess of-the-counter.[forty one] These analogs haven't undergone any of the arduous tests that medication like sildenafil have passed, and so have not known facet-impact profiles.

Furthermore, N-desmethyl metabolite AUC and Cmax values significantly greater by two hundred% and seventy nine%, respectively in topics with severe renal impairment when compared to topics with typical renal function.

At doses over the advised dose selection, adverse reactions ended up just like Those people comprehensive in Table one under but normally were reported more commonly.

Soon after both oral or intravenous administration, sildenafil is excreted as metabolites predominantly during the feces (close to 80% of administered oral dose) and also to a lesser extent inside the urine (around thirteen% with the administered oral dose).

Subjects while in the examine documented this acquiring as challenges in discriminating blue/inexperienced. An analysis of visual functionality website at doses as many as two times the maximum proposed dose uncovered no outcomes of VIAGRA on visual acuity, intraocular strain, or pupillometry.

VIAGRA includes sildenafil, which is identical drugs present in An additional drug identified as REVATIO. REVATIO is utilized to deal with a rare disorder known as pulmonary arterial hypertension (PAH).

Whenever you’re sexually stimulated, Viagra could make your erect penis more substantial than common. It's because the drug increases the level of blood stream on your penis, raising its size.

i.d.) resulted within a sixty three% lower of sildenafil AUC as well as a 55% minimize in sildenafil Cmax . Concomitant administration of sturdy CYP3A4 inducers, like rifampin, is predicted to result in larger decreases in plasma levels of sildenafil.

Sildenafil should not be applied if sexual exercise is inadvisable on account of fundamental cardiovascular hazard components.[31]

This facet effect takes place because of the way Viagra performs. It relaxes your blood vessels and improves blood movement through your body. And this can cause headache sometimes.